Higuchi connors phase solubility techniques.

Phase solubility studies were performed by the method previously reported by Higuchi and Connors . Briefly, excess amounts of darifenacin were added to 20 mL of aqueous solutions containing various concentrations of Hp βCD ... T. Higuchi and K. Connors, “Phase solubility techniques,” Advances in Analytical Chemistry and …

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Abstract The present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone hydrochloride. The solvent evaporation method was used to formulate the solid dispersion resulted increased dissolution rate, bioavailability and stability.The complexation of diosmin with βCD and HPβCD both indicated an AL type of phase-solubility diagrams, and the apparent stability constants (Kc) was found to be 222.13 and 200.08 M(-1 ...Jun 15, 2019 · Solubility phase diagrams were created to evaluate the molar ratios of GAZ/βCD and GAZ/γCD inclusion complexes and their stability in aqueous solution (Fig. 2).The solubility of GAZ increased linearly with the added concentrations of βCD and γCD and produced an A L solubility phase diagram according to the classification by Higuchi, Connors et al. [12] A-type diagrams are formed when the ... All the phase-solubility diagrams were of type A except the diagrams of hydrocortisone in γCD and 80/20 γCD/HPγCD solutions were of B S-type according to the Higuchi-Connor classification system. 22 The slopes of the initial linear sections of the diagrams were determined and both the apparent stability constants (K 1:1) and the …method described by Higuchi & Connors et al [18]. Excess NSF (100 mg) was added to a 50 m L . ... [18] Higuchi T and Connors K A 1965 Phase solubility techniques Advances in Analyt ical Chemistry .

T. Higuchi, K. A. Connors, "Phase Solubility Techniques," Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Binary and Ternary Complexes of Arteether β-CD - Characterization, Molecular Modeling and in Vivo StudiesMoreover, phase-solubility analysis shows that propyl-paraben and ethylparaben, at room temperature, can also form solid solutions whose solubility is related to the composition of the solid phase at equilibrium. ... T. Higuchi, A. Connors. Phase-solubility Techniques. Adv. Anal. Chem. Instr., 4 (1965), pp. 117-212. View in Scopus …In the phase-solubility diagram, the slope was lower than the unit, and the inclusion ratio of BA–β-CD was 1:1. The apparent stability constant (K 1:1) obtained from the Higuchi–Connors formula was 1.3094 × 10 3 mol −1, which showed the existence of favourable interactions. A larger K 1:1 value corresponded to a higher BA solubility ...

The shake-fl ask method proposed by Higuchi and Connors is the most reliable and widely used solubility measurement method. ... K. A. Connors, Phase-solubility techniques, Adv. Anal. Chem. Instr ...

Phase solubility analysis was performed according to the method reported by Higuchi and Conners . An excess amount of RIF was added into a glass vial containing 1 mL of PBS solution (pH = 7.4) with various concentrations of ACB (0, 20, 40, 60, 80, 100 mM, respectively). ... Higuchi, T., Connors, K.A.: Phase-solubility techniques. Adv. …Abstract. The interaction between ibuprofen and maltodextrins with different dextrose equivalent was studied in solution and solid state in order to investigate the effect on the solubility of ibuprofen and to determine their usefulness in terms of chiral recognition. Apparent binding constants were calculated using nuclear magnetic resonance ...The linear phase solubility diagram follows the A L-type model according to Higuchi and Connors (1965), suggesting the inclusion complex formed between BBH (guest) and β-CD (host) is in molar ratio of 1:1. It is well-known that the most common type of CDs complexes is the 1:1 drug/cyclodextrin complex where one drug molecule forms a …The objective of the present investigation was to formulation development of solid dispersion of voriconazole using hot-melt, solvent evaporation and combination of these two methods together with Gelucire® 44/14, polaxamer 188 and polyvinyl pyrrolidone (PVP) K30 and the different characteristics like drug content analysis and in vitro release of the solid dispersions were investigated.

Phase solubility test was performed according to the method of Higuchi and Connors . An excess amount of camphor was added to aqueous CD (HPβCD and HPγCD) solutions, and the suspensions were shaken at RT. After equilibrium was achieved at the end of 48 h, the suspensions were filtered with 0.45 μm membrane filter.

Oct 15, 2013 · Fig. 2 sums up the results of the phase-solubility studies performed and analyzed using the approach described by Brewster and Loftsson (2007) and Higuchi and Connors (1965). For this study, a range of CD concentrations were selected which cover the maximum solubility of CDs in water at room temperature: 0–160 mM for 2-O-MBCD and 0–320 mM ...

Jun 15, 2019 · Solubility phase diagrams were created to evaluate the molar ratios of GAZ/βCD and GAZ/γCD inclusion complexes and their stability in aqueous solution (Fig. 2).The solubility of GAZ increased linearly with the added concentrations of βCD and γCD and produced an A L solubility phase diagram according to the classification by Higuchi, Connors et al. [12] A-type diagrams are formed when the ... The effect of β-CD on the solubility of atorvastatin was investigated according to the phase solubility technique reported by Higuchi and Connors . Excess amounts of atorvastatin were added to 20 mL of either double-distilled water or aqueous solutions containing increasing concentrations of CDs, ranging from 5 to 15% w/w, in a …[Article] - Phase Solubility Techniques I'm having a really hard time even finding a link to this article, but everyone cites it: Higuchi, T.; Connors, K. A., 1965. Adv.Fig. 1 shows the phase solubility diagrams of sulfamethizole with the cyclodextrins used, BCD and HPBCD, at 37°C. The solubility of the drug increased linearly as a function of the CD concentration, a feature of the A L-type complex, showing that water-soluble complexes exit in solution.Phase solubility analyses of F-Asta and Asta-E with HPβ-CD were performed following procedures similar to the ones reported previously (Higuchi & Connors, 1965; Schönbeck et al., 2017 ...The solubilities of voriconazole, ketoconazole, and clotrimazole with and without hydroxybutenyl-β-cyclodextrin (HBenBCD) in aqueous media were examined. The solubility of these antifungal drugs was significantly improved by complexation with HBenBCD. Both the pH and the type of buffer used to adjust the medium pH had a very significant effect on drug solubilities and the apparent binding ...

The present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone ...The solubilizing potential and complexing tendencies of six cyclodextrins (CyD) with nifedipine in aqueous solution were evaluated using phase solubility methods. Solubility curves of nifedipine with β-CyD, 2-hydroxypropyl-β-CyD (2HP-β-CyD) and 2-hydroxypropyl-γ-cyclodextrin (2HP-γ-CyD) were classified as type AL, while for heptakis (2,6-dimethyl)-β-CyD (DIMEB), randomly methylated-β ...Citation University of Kansas. Kenneth Spencer Research Library Personal papers of Takeru Higuchi (PP 359) Articles arranged alphabetically by title: Higuchi A-Z; Higuchi et. al. A-Z Higuchi and Connors, "Phase-Solubility Techniques,", 1964 Dates Creation: 1964 Collapse All Get at Spencer Box: 11, Folder: 35 (Mixed Materials) Repository DetailsT. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following …Phase Solubility Studies. Phase solubility studies were carried out at room temperature (21 ± 1°C) following the method of Higuchi and Connors . Excess amounts of OME were weighed in glass flasks to which 10 ml of boric/borate buffer pH = 10 were added. These flasks contained increasing amounts of βCD (0–1.5%, w/v) or MβCD (0–5%, w/v).

Phase solubility study. Classification of inclusion complex formation and stability of the inclusion compounds were evaluated by phase solubility study (Higuchi & Connors, 1965). An excess of black pepper oil was added to 10 mL aqueous solutions of HPβCD ranging in concentration from 0 to 10 mmol/L and incubated at 25 and 35 °C for …

... Higuchi-Connors phase solubility method. この論文は、ヒグチコンノル相溶解法 ... techniques including Fourier Transform Infrared Spectroscopy (FTIR) and ...T K Higuchi. T K Higuchi. Phase solubility techniques ... Phase solubility techniques. T K Higuchi. 1, A Connors. 1. View details (2 authors) Volume: 4, Pages: 212 - 217. Published: Jan 1 ... Solubility. Phase diagram. Hildebrand solubility parameter. Paper Details. Title. Phase solubility techniques. Published Date. Jan 1, 1965. Volume. 4 ...To determine binding constants by Higuchi and Connors method, the acids solubility was determined by CZE after their agitation in the solutions of HP-γ-CD (with 0.6 molar substitution) at 25 °C for 3 days. The dependences of acids solubility on HP-γ-CD concentration deviated from straight line in the range of high concentration (A N mode ...Phase Solubility Studies. Phase solubility studies were carried out at room temperature (21 ± 1°C) following the method of Higuchi and Connors . Excess amounts of OME were weighed in glass flasks to which 10 ml of boric/borate buffer pH = 10 were added. These flasks contained increasing amounts of βCD (0–1.5%, w/v) or MβCD (0–5%, w/v).Fig. 2 sums up the results of the phase-solubility studies performed and analyzed using the approach described by Brewster and Loftsson (2007) and Higuchi and Connors (1965). For this study, a range of CD concentrations were selected which cover the maximum solubility of CDs in water at room temperature: 0–160 mM for 2-O-MBCD and 0–320 mM ...The phase solubility diagram for Nag in SBE-β-CD system is shown in Fig. 1.The apparent solubility of Nag increased linearly as a function of SBE-β-CD concentration over the studied concentration range, which could be classified as A L type according to Higuchi & Connors. The slope value was less than one, indicating that the formation of …method described by Higuchi & Connors et al [18]. Excess NSF (100 mg) was added to a 50 m L . ... [18] Higuchi T and Connors K A 1965 Phase solubility techniques Advances in Analyt ical Chemistry .

11 Tem 2017 ... Higuchi T, Connors KA. Phase solubility techniques. Advances in Analytical Chemistry and Instrumen- tation. New York, pp. 117–212 ...

In present work, phase solubility analysis were conducted for studying the solubility of terpineol, a natural flavor compound with antifungal and disinfectant action, in 2-hydroxypropyl-β-cyclodextrin (HBCD) and in β-cyclodextrin (BCD) aqueous solutions and for calculating the thermodynamic parameters involved in the complex formation.

One of the most useful and widely applied analytical approaches in this context is the Phase–solubility method described by Higuchi and Connors [42].... Journal Article • DOI • Cyclodextrins in drug delivery: an updated review. It was found that the solubility of ABPP increased linearly as a func- tion of BCD concentration and showed the fea- tures of an AL type (Higuchi and Connors, 1965). The apparent stability constant, K^.^, of the soluble complex at each temperature was calcu- lated according to the equation of Higuchi and Connors (1965), Eqn 1, where 5 is the …The Higuchi–Connors phase-solubility method8) is very often used to ... The phase-distribution method is a very versatile and fast method and has the advantage, ...Phase solubility studies. Degree of complexation between nanosponges and SMX has been studied by phase solubility studies as described by Higuchi and Connors . Briefly, an excess amount of SMX (10 mg/ml), and predetermined concentrations of nanosponges in the range of 0-4% (w/v) were added in volumetric flasks in a PBS medium, and placed on a ...The Higuchi and Connors 30 method was used to classify the phase-solubility profiles. The apparent stability constant ( K 1:1, eq 1 ) and the CE ( eq 2 ) were determined from the slope of the linear phase-solubility diagrams plots of the total drug solubility ([ D t ]) versus total concentration of CD in liquid phase ([CD liq ]) in moles per ...The Higuchi–Connors phase-solubility method8) is very often used to determine K 1:1, as a part of a formulation study. This method is based on the effect of a complex forming lig-and, e.g. CD, on the solubility of the drug. The intrinsic solu-bility (S 0) and the slope of the phase-solubility diagram are then used to calculate K 1:1method described by Higuchi & Connors et al [18]. Excess NSF (100 mg) was added to a 50 m L . ... [18] Higuchi T and Connors K A 1965 Phase solubility techniques Advances in Analyt ical Chemistry .The solubility of CUR increased linearly with increasing concentrations of β-CD, represented as an A L type phase solubility curve (Higuchi & Connors, 1965; Jiang et al., 2019). The results of ANONA of the phase solubility model were provided in Table 1. F value (409.54) was extremely significant (p value < 0.001) suggesting that the model was ...

Types of phase-solubility diagrams according to Higuchi and Connors showing how the total drug solubility changes with increasing CD concentration. A-type diagrams are formed when the drug/CD complex is soluble in the aqueous complexation media and they are usually associated with the water-soluble CD derivatives.[Article] - Phase Solubility Techniques . I'm having a really hard time even finding a link to this article, but everyone cites it: Higuchi, T.; Connors, K. A., 1965. Adv. Anal. Chem. Instrum. 4, 117-212. comment sorted by Best Top New Controversial Q&A Add a …Phase Solubility Studies. Phase solubility studies were carried out based on the methods described by Higuchi and Connors . Excess amount of POS (30 mg) was added to aqueous solutions of β-CD and DM-β-CD with various concentrations (0 to 15.00 mM for β-CD and 0 to 35.00 mM for DM-β-CD).Instagram:https://instagram. estatesales.net marketplacerti response to interventionchina harbour san antoniois smooth sumac edible [Article] - Phase Solubility Techniques . I'm having a really hard time even finding a link to this article, but everyone cites it: Higuchi, T.; Connors, K. A., 1965. Adv. Anal. Chem. Instrum. 4, 117-212. comment sorted by Best Top New Controversial Q&A Add a … pumpkin sheet sethawk talk with bill self Phase Solubility Studies. The solubilization ability of CDs can be quantitatively evaluated by the phase solubility method developed by Higuchi and Connors ().The phase solubility diagram at 25 °C was obtained by plotting the apparent equilibrium concentrations of the drug against βCD concentrations and is reported in Fig. … bessolo The regression analysis (R 2 value 0.9434) of phase solubility data demonstrated A L type curves (Fig. 1 (a)) indicating 1:1 complexation between NCL and HP-β-CD as per Higuchi Connors classification (Higuchi & Connors, 1965). The apparent stability constant of the resultant niclosamide and HP-β-CD complex was found to be 747 M −1.The aqueous solubility of 1 linearly increased as a function of HP-β -CD concentration and showed features of an A -CD concentration and showed features of an AL type diagram. Thermodynamic parameters were obtained by using the temperature dependence of the stability constant at temperatures of between 25 and 37 type diagram.